Rome is shattered by a series of gruesome murders that paint the Eternal City deep red. The suspicion grows that these atrocious crimes are connected with the return of one of the most heinous serial killers of our time - Karl the Butcher.

3 men get stranded on an island. They are captured by this group of people who turn out to be members of a group under the direction of Karl Sr. and his son Karl Jr., who are the famous butcher/slashers from the first two Violent Shit movies. Soon these three men and a bunch of exiles are given a chance to run away from the group members; unlike some others who are brutally murdered. However they decide to fight back and a gory and violent battle ensues.